Si et al. propose an innovative vaccine strategy that utilizes PROTAC technology to create artificially attenuated influenza strains, a strategy that promises to overcome the limitations of traditional vaccine preparation methods. By linking the proteasome-targeting domain (PTD) to a specific protein of the influenza virus, and using the host cell’s ubiquitin-proteasome system, they successfully degraded […]
siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation (Fig. 1). The mRNA is targeted for cleavage through the catalysis of the RISC protein Ago2, a member of the Argonaute family. In addition, other Ago proteins (Ago1, Ago3, and Ago4) […]
During protein synthesis and function, the N-terminal sequence not only determines the starting amino acid of the protein chain but often contains signal sequences that guide proper intracellular localization and processing. These N-terminal signal sequences play crucial roles in secretion, membrane protein insertion, and recombinant protein design. Comprehensive analysis and verification of N-terminal signal sequences […]
Biotinylated nucleotides have emerged as a powerful tool in molecular biology, enabling researchers to explore genetic materials with unprecedented precision and sensitivity. These modified nucleotides, attached to the vitamin biotin, facilitate a variety of applications, including nucleic acid labeling, detection, and manipulation. This article discusses the significance, applications, and benefits of biotinylated nucleotides in the realms […]
Innovation in biotechnology has reached new heights with the advancement of microbial genome editing services. These services enable researchers and industries to modify the genetic makeup of microorganisms, such as bacteria and yeast, with remarkable precision. As a result, microbial genome editing has become a cornerstone in various fields, including agriculture, medicine, and environmental science. […]
In the pharmaceutical industry, excipients play a crucial role in the formulation of medicines. These inactive substances, which are combined with the active pharmaceutical ingredient (API), perform various functions that enhance the effectiveness, stability, and overall performance of drug products. Understanding the common types of excipients is essential for pharmaceutical scientists and formulators, as it aids […]
